The paragraph you're citing talks only about firewall rules you have to set in order for the A/V Edge to work and the 'slight difference in configuration' is just that 50,000-59,999/TCP+UDP has to be opened for inbound and outbound for older servers - no difference in client behavior is mentioned.
This applies to all Lync clients, including Sipe (prehaps except the ancient 2005 Office Communicator which didn't use ICE, STUN and TURN at all). Those ports are used in addition to the 50000-59999 range, which serves direct peer-to-peer connections. You can look at for details on that protocol. 443/TCP and 3478/UDP are for port allocation and transfer of relayed media between client and A/V Edge.
